Acid hydrolases in monocytes from patients with inflammatory bowel disease, chronic liver disease, and rheumatoid arthritis

Ganguly, N. K. ; Lloyd, B. ; Price, C. P. ; Kingham, J. G. C. ; Lloyd, R. S. ; Triger, D. R. ; Wright, Ralph (1978) Acid hydrolases in monocytes from patients with inflammatory bowel disease, chronic liver disease, and rheumatoid arthritis Lancet, 311 (8073). pp. 1073-1075. ISSN 0099-5355

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S01406...

Related URL: http://dx.doi.org/10.1016/S0140-6736(78)90917-0

Abstract

A sensitive technique was used to estimate two acid hydrolases-N-acetyl-β-glucosaminidase (N.A.G.) and β-glucuronidase (B.G.) produced by peripheral-blood monocytes. Enzyme levels were measured after in-vitro incubation of monocytes with or without stimulation by zymosan and endotoxin. Compared with controls, enzyme production and release in inflammatory bowel disease, chronic liver disease, and rheumatoid arthritis were markedly raised. It is suggested that various stimuli, including immunological ones, may be responsible for the release of such. enzymes from monocytes and that such release may be a factor in the production of the chronic inflammation seen in these disorders.

Item Type:Article
Source:Copyright of this article belongs to Lancet.
ID Code:12190
Deposited On:10 Nov 2010 04:29
Last Modified:31 May 2011 11:31

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