Athawale, Paresh R. ; Kalmode, Hanuman P. ; Motiwala, Zenia ; Kulkarni, Kiran A. ; Reddy, D. Srinivasa (2020) Overturning the Peribysin Family Natural Products Isolated from Periconia byssoides OUPS-N133: Synthesis and Stereochemical Revision of Peribysins A, B, C, F, and G Organic Letters, 22 (8). pp. 3104-3109. ISSN 1523-7060
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Official URL: http://doi.org/10.1021/acs.orglett.0c00857
Related URL: http://dx.doi.org/10.1021/acs.orglett.0c00857
Abstract
Herein we report the stereochemical revision of peribysins A, B, C, F, and G, guided by enantiospecific total synthesis starting from (+)-nootkatone. Furthermore, we reconfirmed the absolute stereochemistry of peribysin Q. The highlights of the synthesis are enone transposition and kinetic iodination resulting in separation of diastereomers. Our findings coupled with synthetic and biological data previously reported by Danishefsky's group suggest that the original stereochemistries of peribysins A, B, C, F, and G were misassigned.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society |
| ID Code: | 121809 |
| Deposited On: | 22 Jul 2021 09:19 |
| Last Modified: | 22 Jul 2021 09:19 |
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