An experimental model of ameboma in guinea pig

Bhatti, H. S. ; Bhushnurmath, S. ; Mahajan, R. C. ; Ganguly, N. K. ; Sehgal, R. (1992) An experimental model of ameboma in guinea pig Experimental Parasitology, 74 (3). pp. 283-289. ISSN 0014-4894

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Among the wide variety of clinicopathological manifestations of intestinal amebiasis, amebomas occur rarely and their pathogenesis is not well understood. When cholesterol-fed, 2- to 4-week-old guinea pigs were infected intracecally with a virulent, monoaxenic strain of Entamoeba histolytica, gross and histologically characteristic amebomas developed in 85% of the animals by the 3rd day, in 94% by the 9th day, and in 96% by the 12th day postinfection, by which time most of them had died. Amebomas were confirmed by histopathology. Thus, a model of consistent production of amebomas was documented.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Guinea Pig; Experimental Model; Ameboma; Entamoeba Histolytica
ID Code:12169
Deposited On:10 Nov 2010 04:14
Last Modified:31 May 2011 10:39

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