α-Hydroxymethylation of conjugated nitroalkenes via the Morita–Baylis–Hillman reaction

Rastogi, Namrata ; Namboothiri, Irishi N.N. ; Cojocaru, Miriam (2004) α-Hydroxymethylation of conjugated nitroalkenes via the Morita–Baylis–Hillman reaction Tetrahedron Letters, 45 (24). pp. 4745-4748. ISSN 0040-4039

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Official URL: http://doi.org/10.1016/j.tetlet.2004.04.069

Related URL: http://dx.doi.org/10.1016/j.tetlet.2004.04.069

Abstract

The Morita-Baylis-Hillman reaction (MBHR) of conjugated nitroalkenes has been successfully carried out for the first time. A variety of aromatic and heteroaromatic nitroalkenes react with formaldehyde at room temperature in the presence of stoichiometric amounts of imidazole and catalytic amounts of anthranilic acid in THF providing moderate to good yields of the multifunctional adducts in most of the cases.

Item Type:Article
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ID Code:121602
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