Nifedipine impairs neutrophil respiratory burst. A mechanism other than Calcium channel blockade

Nalini, K. ; Andrabi, K. I. ; Ganguly, N. K. ; Wahi, P. L. (1990) Nifedipine impairs neutrophil respiratory burst. A mechanism other than Calcium channel blockade Molecular and Cellular Biochemistry, 93 (1). pp. 27-34. ISSN 0300-8177

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Official URL: http://www.springerlink.com/index/k009872j1hu402w5...

Related URL: http://dx.doi.org/10.1007/BF00223489

Abstract

Superoxide production by mice neutrophils was inhibited by nifedipine exposure in a dose dependent manner. The inhibition of Ca2+ uptake elicited by nifedipine did not appear to account for the observed effect as the extracellular Ca2+ enrichment and depletion did not produce a significant reversal of the inhibition. Cytosolic free Ca2+ as measured by Quin 2AM fluorescence did not show any significant change, indicating that the effect was independent of the inhibition of Ca2+ influx. In addition nifedipine caused a significant inhibition (p < 0.01) in NADPH oxidase activity. Our data indicates that nifedipine inhibits superoxide production independent of inhibiting Ca2+ inflow and supports the hypothesis that Ca2+ antagonists affect cellular functions by non Ca2+ mediated process as well.

Item Type:Article
Source:Copyright of this article belongs to Springer-Verlag.
Keywords:Neutrophil; Superoxide; Calcium; Nifedipine
ID Code:12156
Deposited On:10 Nov 2010 04:06
Last Modified:31 May 2011 11:17

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