Immunological defect in leprosy patients: altered T-lymphocyte signals

Sharma, Nidhi ; Sharma, V. K. ; Gupta, Anu ; Kaur, Inderjeet ; Ganguly, N. K. (1999) Immunological defect in leprosy patients: altered T-lymphocyte signals FEMS Immunology & Medical Microbiology, 23 (4). pp. 355-362. ISSN 0928-8244

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The early events of activation were studied in paucibacillary (TT/BT) and multibacillary (BL/LL) leprosy patients by stimulation of their lymphocytes with mitogenic agents (calcium ionophore A23187/PMA) and Micobacterium leprae antigen (PGL-1). Maximum proliferation in response to PMA/A23187 and PGL-1 was observed in the BT/TT patients and the control group, respectively. Inositol triphosphate (IP3) and calcium were constitutively elevated in BT/TT and LL/BL patients. PMA/A23187 caused an increase in both IP3 and [Ca2+]i in BT/TT patients and controls. PGL-1 marginally increased IP3 levels in BT/TT patients. In the LL/BL patients, although PMA/A23187 increased IP3 levels, but no change was seen in [Ca2+]i, PGL-1 had no effect. Protein kinase C levels were seen to be associated with particulate fractions in BT/TT patients and were found to increase further in response to PMA/A23187. PGL-1 did not increase translocation of protein kinase C in controls or LL/BL patients. A preactivated and sensitised state of T-lymphocytes was observed in BT/TT patients, responsive to antigen and mitogens, whereas the cells of LL/BL patients were unresponsive to PGL-1. The altered signal transduction events characterised in the MB patients thus correlate well with the anergic state of their cells.

Item Type:Article
Source:Copyright of this article belongs to Federation of European Microbiological Societies.
Keywords:Leprosy; Intracellular Calcium; T-lymphocyte; Inositol Triphosphate; Protein Kinase C
ID Code:12137
Deposited On:10 Nov 2010 04:18
Last Modified:16 May 2016 21:32

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