Naphthoquinone-based chalcone hybrids and derivatives: synthesis and potent activity against cancer cell lines

Jardim, Guilherme A. M. ; Guimarães, Tiago T. ; Pinto, Maria do Carmo F. R. ; Cavalcanti, Bruno C. ; de Farias, Kaio M. ; Pessoa, Claudia ; Gatto, Claudia C. ; Nair, Divya K. ; Namboothiri, Irishi N. N. ; da Silva Júnior, Eufrânio N. (2015) Naphthoquinone-based chalcone hybrids and derivatives: synthesis and potent activity against cancer cell lines MedChemComm, 6 (1). pp. 120-130. ISSN 2040-2503

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Official URL: http://doi.org/10.1039/c4md00371c

Related URL: http://dx.doi.org/10.1039/c4md00371c

Abstract

Novel naphthoquinone-based chalcones were prepared from the reaction between 3-bromo-nor-β-lapachone and amino-chalcones. Lapachone derivatives are also described here. All the substances were evaluated against cancer and normal cell lines and several compounds demonstrated potent antitumor activity.

Item Type:Article
Source:Copyright of this article belongs to The Royal Society of Chemistry.
ID Code:121338
Deposited On:14 Jul 2021 11:41
Last Modified:14 Jul 2021 11:41

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