Effect of iron on early changes in Escherichia coli-induced ascending pyelonephritis in rats

Sharma, S. ; Garg, U. C. ; Ganguly, N. K. ; Sharma, B. K. (1987) Effect of iron on early changes in Escherichia coli-induced ascending pyelonephritis in rats FEMS Microbiology Letters, 41 (3). pp. 295-298. ISSN 0378-1097

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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1574-...

Related URL: http://dx.doi.org/10.1111/j.1574-6968.1987.tb02214.x

Abstract

Uptake of D-glucose, L-lysine and L-proline and the kinetic parameters of alkaline phosphatase and γ-glutamyl-transpeptidase were evaluated in renal brush border membrane (BBM) vesicles prepared from control, pyelonephritic and iron-administered pyelonephritic rats. The uptake of D-glucose and amino acids and Vmax of both the enzymes studied were found to be altered in pyelonephritic and iron-administered pyelonephritic rats, but changes appeared earlier and more severely in iron-administered infected animals than in other infected animals. These early physiological alterations were accompanied by higher bacterial colonisation in iron-administered rats.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons, Inc.
Keywords:Iron;escherichia Coli; Pyelonephritis; Virulence Factor; (Rat)
ID Code:12133
Deposited On:10 Nov 2010 04:19
Last Modified:31 May 2011 11:23

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