Leishmania mitochondrial tRNA importers

Adhya, Samit (2008) Leishmania mitochondrial tRNA importers International Journal of Biochemistry & Cell Biology, 40 (12). pp. 2681-2685. ISSN 1357-2725

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S13572...

Related URL: http://dx.doi.org/10.1016/j.biocel.2007.10.025


The RNA Import Complex (RIC) is a multi-subunit protein complex from the mitochondria of the kinetoplastid protozoon Leishmania tropica that induces transport of tRNA across natural and artificial membranes. Leishmania, Trypanosoma and related genera of the order Kinetoplastidae are early diverging, a typical eukaryotes with unique RNA metabolic pathways, including the import of nucleus-encoded tRNAs into the mitochondrion to complement the deletion of all organelle-encoded tRNA genes. Biochemical and genetic studies of RIC are contributing to greater understanding of the mechanism of import. Additionally, RIC was shown to act as an efficient delivery vehicle for tRNA and other small RNAs into mitochondria within intact mammalian cells, indicating its applicability to the management of diseases caused by mitochondrial mutations.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:tRNA; Import; Mitochondria; Complex; Leishmania
ID Code:12107
Deposited On:10 Nov 2010 04:30
Last Modified:10 Nov 2010 04:30

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