Fang, Shijing ; Panettieri, Reynold A. ; Agrawal, Anurag ; Murphy, Edwin C. ; Parikh, Indu ; Adler, Kenneth B. (2011) Pharmacology Studies Demonstrate A Dual Mechanism Of Action Of Bio-11006 As A Potential Therapeutic For COPD In: C39 NOVEL THERAPEUTIC OPTIONS IN AIRWAYS DISEASE, Thematic Poster Session, May 17 2011, Colorado Convention Center.
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Official URL: http://doi.org/10.1164/ajrccm-conference.2011.183....
Related URL: http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_MeetingAbstracts.A4507
Abstract
Mucus hypersecretion and airway inflammation are two of the major underlying pathogenic causes of COPD. The myristoylated alanine rich C-kinase substrate (MARCKS) is a key protein involved in the secretory pathway controlling mucin secretion and degranulation of inflammatory cells. A ten amino acid peptide (BIO-11006) has been identified that effectively inhibits mucin secretion and release of inflammatory mediators in various in vitro and in vivo models by competitively inhibiting MARCKS protein function. This abstract is funded by: R37 NHLBI grant awarded to my mentor, Dr. Kenneth B. Adler.
| Item Type: | Conference or Workshop Item (Paper) |
|---|---|
| Source: | Copyright of this article belongs to American Thoracic Society. |
| ID Code: | 121009 |
| Deposited On: | 08 Jul 2021 08:41 |
| Last Modified: | 08 Jul 2021 08:41 |
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