A novel and green protocol for two-carbon homologation: a direct amino acid/K2CO3-catalyzed four-component reaction of aldehydes, active methylenes, Hantzsch esters and alkyl halides

Ramachary, Dhevalapally B. ; Kishor, M. ; Ramakumar, K. (2006) A novel and green protocol for two-carbon homologation: a direct amino acid/K2CO3-catalyzed four-component reaction of aldehydes, active methylenes, Hantzsch esters and alkyl halides Tetrahedron Letters, 47 (5). pp. 651-656. ISSN 0040-4039

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Official URL: http://doi.org/10.1016/j.tetlet.2005.11.128

Related URL: http://dx.doi.org/10.1016/j.tetlet.2005.11.128

Abstract

A novel and green approach for the two-carbon homologation of aldehydes using amino acid catalysis has been developed and further extended to the generation of pharmaceutically active cyano-esters via four-component reactions in one-pot.

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