A new organocatalyst for Friedel–Crafts alkylation of 2-naphthols with isatins: application of an organo-click strategy for the cascade synthesis of highly functionalized molecules

Ramachary, Dhevalapally B. ; Babul Reddy, G. ; Mondal, Rumpa (2007) A new organocatalyst for Friedel–Crafts alkylation of 2-naphthols with isatins: application of an organo-click strategy for the cascade synthesis of highly functionalized molecules Tetrahedron Letters, 48 (43). pp. 7618-7623. ISSN 0040-4039

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Official URL: http://doi.org/10.1016/j.tetlet.2007.08.129

Related URL: http://dx.doi.org/10.1016/j.tetlet.2007.08.129

Abstract

The three-component Friedel–Crafts alkylation/Huisgen cycloaddition (FCA/HC) reactions of 2-naphthols, substituted isatins and azides under dimethylamino-ethanol/CuI-catalysis furnished highly functionalized 1,4-disubstituted [1,2,3]-triazoles.

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