Direct Catalytic Asymmetric Synthesis of Highly Functionalized 2-Methylchroman-2,4-diols via Barbas-List Aldol Reaction

Ramachary, Dhevalapally B. ; Sakthidevi, Rajasekar (2009) Direct Catalytic Asymmetric Synthesis of Highly Functionalized 2-Methylchroman-2,4-diols via Barbas-List Aldol Reaction Chemistry - A European Journal, 15 (18). pp. 4516-4522. ISSN 0947-6539

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Official URL: http://doi.org/10.1002/chem.200900066

Related URL: http://dx.doi.org/10.1002/chem.200900066

Abstract

chemical process for the synthesis of highly substituted aldol↔lactol products was achieved for the first time through the asymmetric Barbas–List aldol (BLA) reaction of 2-hydroxybenzaldehydes with acetone in the presence of a catalytic amount of trans-4-OH-L-proline (see scheme).

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Deposited On:05 Jul 2021 06:15
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