Functional delivery of a cytosolic tRNA into mutant mitochondria of human cells

Mahata, Bidesh ; Mukherjee, Saikat ; Mishra, Sumita ; Bandyopadhyay, Arun ; Adhya, Samit (2006) Functional delivery of a cytosolic tRNA into mutant mitochondria of human cells Science, 314 (5798). 471- 474. ISSN 0036-8075

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Official URL: http://scienceonline.org/cgi/content/abstract/314/...

Related URL: http://dx.doi.org/10.1126/science.1129754

Abstract

Many maternally inherited and incurable neuromyopathies are caused by mutations in mitochondrial (mt) transfer RNA (tRNA) genes. Kinetoplastid protozoa, including Leishmania, have evolved specialized systems for importing nucleus-encoded tRNAs into mitochondria. We found that the Leishmania RNA import complex (RIC) could enter human cells by a caveolin-1-dependent pathway, where it induced import of endogenous cytosolic tRNAs, including tRNALys, and restored mitochondrial function in a cybrid harboring a mutant mt tRNALys (MT-TK) gene. The use of protein complexes to modulate mitochondrial function may help in the management of such genetic disorders.

Item Type:Article
Source:Copyright of this article belongs to American Association for the Advancement of Science.
ID Code:12068
Deposited On:10 Nov 2010 04:47
Last Modified:30 Dec 2010 09:12

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