Organocatalytic Asymmetric Formal [3+2] Cycloaddition as a Versatile Platform to Access Methanobenzo[7]annulenes

Ramachary, Dhevalapally B. ; Anif Pasha, Mohammed ; Thirupathi, Guguloth (2017) Organocatalytic Asymmetric Formal [3+2] Cycloaddition as a Versatile Platform to Access Methanobenzo[7]annulenes Angewandte Chemie International Edition, 56 (42). pp. 12930-12934. ISSN 1433-7851

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Official URL: http://doi.org/10.1002/anie.201706557

Related URL: http://dx.doi.org/10.1002/anie.201706557

Abstract

Pharmaceutically and structurally important methanobenzo[7]annulenes were synthesized in very good yields with excellent enantio- and diastereoselectivities through an unprecedented organocatalytic formal [3+2] cycloaddition from readily available 2-alkyl-3-hydroxynaphthalene-1,4-diones and alkyl vinyl ketones.

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Deposited On:03 Jul 2021 05:59
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