Hema, Kuntrapakam ; Sureshan, Kana M. (2020) β‐Sheet to Helical‐Sheet Evolution Induced by Topochemical Polymerization: Cross‐α‐Amyloid‐like Packing in a Pseudoprotein with Gly‐Phe‐Gly Repeats Angewandte Chemie, 132 (23). pp. 8939-8944. ISSN 0044-8249
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Official URL: http://doi.org/10.1002/ange.201914975
Related URL: http://dx.doi.org/10.1002/ange.201914975
Abstract
A designed dipeptide with azide and alkyne groups at its termini adopts β-sheet packing in its crystal and undergoes single-crystal-to-single-crystal polymerization via topochemical azide-alkyne cycloaddition to evolve into a pseudoprotein with interesting helical-sheet packing in its crystals. This helical-sheet orientation in the pseudoprotein crystal resembles the novel cross-α-amyloids, wherein α-helical protein assembles laterally.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley and Sons, Inc. |
| ID Code: | 119948 |
| Deposited On: | 19 Jun 2021 05:57 |
| Last Modified: | 19 Jun 2021 05:57 |
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