Gokul, Gopinathan ; Khosla, Sanjeev (2012) DNA Methylation and Cancer Subcellular Biochemistry, 61 . Springer Nature Switzerland AG, Epigenetics: Development and Disease, pp. 597-625. ISBN 978-94-007-4525-4
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Official URL: http://doi.org/10.1007/978-94-007-4525-4_26
Related URL: http://dx.doi.org/10.1007/978-94-007-4525-4_26
Abstract
Cancer has been considered a genetic disease with a wide array of well-characterized gene mutations and chromosomal abnormalities. Of late, aberrant epigenetic modifications have been elucidated in cancer, and together with genetic alterations, they have been helpful in understanding the complex traits observed in neoplasia. "Cancer Epigenetics" therefore has contributed substantially towards understanding the complexity and diversity of various cancers. However, the positioning of epigenetic events during cancer progression is still not clear, though there are some reports implicating aberrant epigenetic modifications in very early stages of cancer. Amongst the most studied aberrant epigenetic modifications are the DNA methylation differences at the promoter regions of genes affecting their expression. Hypomethylation mediated increased expression of oncogenes and hypermethylation mediated silencing of tumor suppressor genes are well known examples. This chapter also explores the correlation of DNA methylation and demethylation enzymes with cancer.
| Item Type: | Book |
|---|---|
| Source: | Copyright of this article belongs to Springer Nature Switzerland AG. |
| Keywords: | Histone Modification; Imprint Gene; Global Hypomethylation; Methyl Binding Protein; Pericentromeric Satellite. |
| ID Code: | 119923 |
| Deposited On: | 18 Jun 2021 12:25 |
| Last Modified: | 18 Jun 2021 12:25 |
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