Hopping-Mediated Anion Transport through a Mannitol-Based Rosette Ion Channel

Saha, Tanmoy ; Dasari, Sathish ; Tewari, Debanjan ; Prathap, Annamalai ; Sureshan, Kana M. ; Bera, Amal K. ; Mukherjee, Arnab ; Talukdar, Pinaki (2014) Hopping-Mediated Anion Transport through a Mannitol-Based Rosette Ion Channel Journal of the American Chemical Society, 136 (40). pp. 14128-14135. ISSN 0002-7863

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Official URL: http://doi.org/10.1021/ja506278z

Related URL: http://dx.doi.org/10.1021/ja506278z

Abstract

Artificial anion selective ion channels with single-file multiple anion-recognition sites are rare. Here, we have designed, by hypothesis, a small molecule that self-organizes to form a barrel rosette ion channel in the lipid membrane environment. Being amphiphilic in nature, this molecule forms nanotubes through intermolecular hydrogen bond formation, while its hydrophobic counterpart is stabilized by hydrophobic interactions in the membrane. The anion selectivity of the channel was investigated by fluorescence-based vesicle assay and planar bilayer conductance measurements. The ion transport by a modified hopping mechanism was demonstrated by molecular dynamics simulation studies.

Item Type:Article
Source:Copyright of this article belongs to American Chemical Society.
ID Code:119893
Deposited On:18 Jun 2021 06:35
Last Modified:18 Jun 2021 06:35

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