Vidyasagar, Adiyala ; Sureshan, Kana M. (2014) Total Synthesis and Glycosidase Inhibition Studies of (-)-Gabosine J and Its Derivatives European Journal of Organic Chemistry, 2014 (11). pp. 2349-2356. ISSN 1434-193X
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Official URL: http://doi.org/10.1002/ejoc.201301782
Related URL: http://dx.doi.org/10.1002/ejoc.201301782
Abstract
Gabosine J and its two synthetic analogues were prepared by a chiral pool synthesis that started from D-mannitol. Gabosine J was synthesized in 14 steps in a 13 % overall yield. Preliminary biological investigations suggest that (–)-gabosine J inhibits α-mannosidase and its reduced forms, gabosinol J-α and gabosinol J-β, inhibit β-galactosidase and β-glucosidase, respectively.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley and Sons. |
| ID Code: | 119886 |
| Deposited On: | 18 Jun 2021 06:11 |
| Last Modified: | 18 Jun 2021 06:11 |
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