Samai, Subhasis ; Nandi, Ganesh Chandra ; Singh, Pallavi ; Singh, M.S. (2009) l-Proline: an efficient catalyst for the one-pot synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles Tetrahedron, 65 (49). pp. 10155-10161. ISSN 0040-4020
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Official URL: http://doi.org/10.1016/j.tet.2009.10.019
Related URL: http://dx.doi.org/10.1016/j.tet.2009.10.019
Abstract
A simple highly versatile and efficient synthesis of 2,4,5-trisubstituted imidazoles is achieved by three-component cyclocondensation of 1,2-dicarbonyl compound, aldehyde and ammonium acetate using l-proline as a catalyst in methanol at moderate temperature. To explore the utility of this method 1,2,4,5-tetrasubstituted imidazoles were also synthesized. The key advantages of this process are high yields, cost effectiveness of catalyst, easy work-up and purification of products by non-chromatographic methods.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 119676 |
| Deposited On: | 16 Jun 2021 07:01 |
| Last Modified: | 16 Jun 2021 07:01 |
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