Atom-efficient and environment-friendly multicomponent synthesis of amidoalkyl naphthols catalyzed by P2O5

Nandi, Ganesh Chandra ; Samai, Subhasis ; Kumar, Ram ; Singh, M.S. (2009) Atom-efficient and environment-friendly multicomponent synthesis of amidoalkyl naphthols catalyzed by P2O5 Tetrahedron Letters, 50 (51). pp. 7220-7222. ISSN 0040-4039

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Official URL: http://doi.org/10.1016/j.tetlet.2009.10.055

Related URL: http://dx.doi.org/10.1016/j.tetlet.2009.10.055

Abstract

An atom-efficient and environment-friendly approach for the synthesis of amidoalkyl naphthols (4a–x) via multicomponent one-pot reaction of 2-naphthol (1), aromatic aldehyde (2) and amide (3) catalyzed by P2O5 has been developed. The present approach offers several advantages such as reduced reaction times, moderate temperature, higher yields, eco-friendly reaction condition, easy purification and economic availability of the catalyst.

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