Samai, Subhasis ; Nandi, Ganesh Chandra ; Singh, M.S. (2010) An efficient and facile one-pot synthesis of propargylamines by three-component coupling of aldehydes, amines, and alkynes via C–H activation catalyzed by NiCl2 Tetrahedron Letters, 51 (42). pp. 5555-5558. ISSN 0040-4039
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Official URL: http://doi.org/10.1016/j.tetlet.2010.08.043
Related URL: http://dx.doi.org/10.1016/j.tetlet.2010.08.043
Abstract
NiCl2 was found to be a highly efficient and effective catalyst for the one-pot three-component (A3) coupling of aldehydes, amines, and alkynes to produce propargylamines in nearly quantitative yields. Structurally divergent aldehydes, amines, and alkynes were converted into the corresponding propargylamines. No co-catalyst or activator is needed and water is the only byproduct of this novel protocol.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 119669 |
| Deposited On: | 16 Jun 2021 06:21 |
| Last Modified: | 16 Jun 2021 06:21 |
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