One-Pot Two-Component [3 + 2] Cycloaddition/Annulation Protocol for the Synthesis of Highly Functionalized Thiophene Derivatives

Nandi, Ganesh Chandra ; Samai, Subhasis ; Singh, Maya Shankar (2011) One-Pot Two-Component [3 + 2] Cycloaddition/Annulation Protocol for the Synthesis of Highly Functionalized Thiophene Derivatives Journal of Organic Chemistry, 76 (19). pp. 8009-8014. ISSN 0022-3263

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Official URL: http://doi.org/10.1021/jo200685e

Related URL: http://dx.doi.org/10.1021/jo200685e

Abstract

4-dimethylaminopyridine (DMAP) promotes an efficient and experimentally rapid protocol for the synthesis of 2,3-dicarboalkoxy-4-aroyl/heteroaroyl/alkanoyl thiophenes in high yields via 1-2 (C-S) and 3-4 (C-C) bond connections in only 3-5 min in DCM at room temperature. This method allows a clean and general synthesis of previously inaccessible and synthetically demanding thiophenes.

Item Type:Article
Source:Copyright of this article belongs to American Chemical Society.
ID Code:119659
Deposited On:16 Jun 2021 05:26
Last Modified:16 Jun 2021 05:26

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