Solvent-free sonochemical one-pot three-component synthesis of 2H-indazolo[2,1-b]phthalazine-1,6,11-triones and 1H-pyrazolo[1,2-b]phthalazine-5,10-diones

Shukla, Gaurav ; Verma, Rajiv K. ; Verma, Girijesh K. ; Singh, Maya Shankar (2011) Solvent-free sonochemical one-pot three-component synthesis of 2H-indazolo[2,1-b]phthalazine-1,6,11-triones and 1H-pyrazolo[1,2-b]phthalazine-5,10-diones Tetrahedron Letters, 52 (52). pp. 7195-7198. ISSN 0040-4039

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Official URL: http://doi.org/10.1016/j.tetlet.2011.10.136

Related URL: http://dx.doi.org/10.1016/j.tetlet.2011.10.136

Abstract

A rapid and efficient one-pot three-component protocol for the synthesis of 2H-indazolo[2,1-b]phthalazine-1,6,11-triones 4 and 1H-pyrazolo[1,2-b]phthalazine-5,10-diones 6 has been developed by domino coupling of phthalhydrazide, 1,3-diketones, and aldehydes under solvent-free conditions at 80 °C as well as under solvent-free ultrasound irradiation at room temperature promoted by (S)-camphorsulfonic acid.

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