Single electroconvulsive shock and dopamine autoreceptors

Gangadhar, BN ; Ramadevi, G ; Andrade, C ; Pradhan, N (1990) Single electroconvulsive shock and dopamine autoreceptors Indian Journal of Psychiatry, 32 (4). pp. 302-304. ISSN 0019-5545

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Dopamine (DA) auto receptor down regulation has been suggested to mediate the therapeutic effect of antidepressant treatments including electroconvulsive therapy (ECT). Suggestion has also been made that a single ECT may have antidepressant potential via such a mechanism. The present study was therefore conducted to assess the effects ill a single electroconvulsive shock (ECS) on dopamine auto receptors in the rat brain. Using the low dose, Apomorphine-induccd by pomotilily behavioural paradigm, DA auto receptor function was studied one and eight days alter a single true ECS, and 8 days alter a single sham ECS. No significant difference was observed between the groups. The results suggest that single ECS exerts neither acute nor time-dependant DA auto receptor effects; however, the issue in certain aspects remains open for further study.

Item Type:Article
Source:Copyright of this article belongs to Indian Psychiatric Society.
ID Code:119458
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