P300 amplitude in non-bipolar, melancholic depression

Gangadhar, B.N. ; Ancy, J. ; Janakiranaiah, N. ; Umapathy, C. (1993) P300 amplitude in non-bipolar, melancholic depression Journal of Affective Disorders, 28 (1). pp. 57-60. ISSN 0165-0327

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Official URL: http://doi.org/10.1016/0165-0327(93)90077-W

Related URL: http://dx.doi.org/10.1016/0165-0327(93)90077-W


P300 event related potential (ERP) was recorded using the auditory ‘oddball’ paradigm in 17 melancholic, drug-free depressive patients and 22 normal controls. Repeat ERP recordings were obtained from 13 patients after recovery with ECT. Pretreatment P300 latencies were not different between patients and controls, nor did they change in the depressives following recovery. Pretreatment P300 amplitudes in depressives were snaller (P <0.02) than in controls and negatively correlated with severity (P <0.05). P300 amplitudes significantly increased in patients following recovery (P <0.05) and normalized. P300 may be a state marker for melancholic depression.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Event Related Potential; P300; Melancholia.
ID Code:119446
Deposited On:13 Jun 2021 12:39
Last Modified:13 Jun 2021 12:39

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