Measuring the corpus callosum in schizophrenia: A technique with neuroanatomical and cytoarchtectural basis

Venkatasubramanian, Ganesan ; Jayakumar, PN ; Gangadhar, BN ; Janakiramaiah, N ; Subbakrishna, D ; Keshavan, Matcheri (2003) Measuring the corpus callosum in schizophrenia: A technique with neuroanatomical and cytoarchtectural basis Neurology India, 51 . pp. 189-92. ISSN 0028-3886

Full text not available from this repository.

Official URL:

Related URL: 14571000


Background: Corpus Callosum (CC) abnormalities have been described in schizophrenia. Review of CC measurement methods in schizophrenia reveals inconsistency and lack of neuroanatomical basis. Aims: The aims of the study are to describe a new CC measurement method with valid a neuroanatomical and cytoarchitectural basis and to demonstrate inter-rater reliability for the same. Settings and design: The study was performed in the National Institute of Mental Health & Neurosciences, Bangalore, India. Ours is a cross-sectional study in which both the first author and senior neuroradiologist were blind to clinical details. Material and methods: We report a reliable, semi-automated CC measuring technique with a neuroanatomical and cytoarchitectural basis tested in a group of 16 never-treated schizophrenia patients using 1-mm thick, objectively defined midsagittal MRI section. Measurement on coded slices using scion image software ensured elimination of rater bias. Statistical analysis used: The statistical analysis used for assessing inter-rater reliability is intraclass correlation coefficient analysis. Results: The intraclass correlation coefficients for the CC measurements were as follows: CC Area = 0.93; Anterior CC area = 0.84; Area of body of the CC = 0.83; Area of CC isthmus = 0.65; Area of CC splenium = 0.88; maximum antero-posterior distance of CC = 0.96. Conclusion: Measurements showed good inter-rater reliability. The methodology demonstrated in our study is simple, relevant, reliable and can be used for future schizophrenia research.

Item Type:Article
Source:Copyright of this article belongs to Medknow Publications.
ID Code:119175
Deposited On:08 Jun 2021 12:07
Last Modified:08 Jun 2021 12:07

Repository Staff Only: item control page