Neurological soft signs in never-treated schizophrenia

Venkatasubramanian, G. ; Latha, V. ; Gangadhar, B. N. ; Janakiramaiah, N. ; Subbakrishna, D. K. ; Jayakumar, P. N. ; Keshavan, M. S. (2003) Neurological soft signs in never-treated schizophrenia Acta Psychiatrica Scandinavica, 108 (2). pp. 144-146. ISSN 0001-690X

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Objective: Studies of Neurological Soft Signs (NSS) in schizophrenia are confounded by handedness, inconsistent methodology, and prior treatment with neuroleptics. The study objective is to examine NSS in never-treated schizophrenia. Method: We examined the NSS in treatment-naïve schizophrenia patients (n = 21) and age, sex, education, and handedness matched normal controls (n = 21) using the modified Neurological Evaluation Scale with good inter-rater reliability. Results: Schizophrenia patients had significantly more NSS than normals. No significant correlation was found between illness duration and NSS. Conclusion: Higher neurological signs in never-treated patients and their lack of association with illness duration suggest neurodevelopmental etiopathogenesis of schizophrenia.

Item Type:Article
Source:Copyright of this article belongs to John Wiley & Sons, Inc.
Keywords:Neurological Soft Signs; Never-Treated Schizophrenia.
ID Code:119173
Deposited On:08 Jun 2021 11:58
Last Modified:08 Jun 2021 11:58

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