Insulin and Insulin-Like Growth Factor-1 Abnormalities in Antipsychotic-Naive Schizophrenia

Venkatasubramanian, Ganesan ; Chittiprol, Seetharamaiah ; Neelakantachar, Narendran ; Naveen, Magadi N. ; Thirthall, Jagadisha ; Gangadhar, Bangalore N. ; Shetty, K. Taranath (2007) Insulin and Insulin-Like Growth Factor-1 Abnormalities in Antipsychotic-Naive Schizophrenia American Journal of Psychiatry, 164 (10). pp. 1557-1560. ISSN 0002-953X

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Objective: The purpose of this study was to examine the evidence for the insulin-like growth factor-1 (IGF-1) deficiency hypothesis in the pathogenesis of schizophrenia. Method: The authors examined the fasting plasma levels of glucose, insulin, IGF-1, and cortisol in antipsychotic-naive schizophrenia patients (N=44) relative to age- and sex-matched healthy comparison subjects (N=44). Patients and comparison subjects were also matched for anthropometric measures and physical activity. Results: Schizophrenia patients had a significantly higher mean plasma insulin level as well as a significantly higher mean insulin resistance score relative to healthy comparison subjects. The mean plasma IGF-1 level was significantly lower in patients. IGF-1 levels had a significant negative correlation with plasma insulin levels. The total positive symptoms score as well as the hallucinations subscore had a significant inverse relationship with IGF-1 levels. Conclusions: Deficient IGF-1 might underlie insulin resistance in schizophrenia. The IGF-1 deficit in antipsychotic-naive schizophrenia patients and its significant correlation with psychopathology scores suggest that IGF-1 might be potentially involved in the pathogenesis of schizophrenia.

Item Type:Article
Source:Copyright of this article belongs to American Psychiatric Publishing Inc.
ID Code:119127
Deposited On:08 Jun 2021 06:33
Last Modified:08 Jun 2021 06:33

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