Olanzapine-Induced Clinical Seizure

Behere, Rishikesh V. ; Anjith, Divakaran ; Rao, Naren P. ; Venkatasubramanian, Ganesan ; Gangadhar, Bangalore N. (2009) Olanzapine-Induced Clinical Seizure Clinical Neuropharmacology, 32 (5). pp. 297-298. ISSN 0362-5664

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Official URL: http://doi.org/10.1097/WNF.0b013e3181a7fd00

Related URL: http://dx.doi.org/10.1097/WNF.0b013e3181a7fd00


Atypical antipsychotics are known to be associated with electroencephalogram abnormalities. Olanzapine can lower seizure threshold and induce epileptiform discharges. However in patients on olanzapine for the treatment of a primary psychiatric disorder, clinical seizure is a rare occurence. We report the case of a 25-year-old man with a diagnosis of paranoid schizophrenia with obsessive-compulsive disorder of 8 years' duration who developed new-onset generalized tonic-clonic seizure with exposure to olanzapine. Electroencephalogram showed epileptiform discharges; results of computed tomographic scan and metabolic investigations were normal. His antipsychotic was changed to haloperidol, and the patient showed a significant improvement in psychotic symptoms with no recurrence of seizures and did not require anticonvulsant therapy. Olanzapine has a profile similar to that of clozapine and shares its seizure-inducing potential. Typical antipsychotics such as haloperidol might be a safer option for such patients.

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Deposited On:08 Jun 2021 05:50
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