Early Stress Evokes Age-Dependent Biphasic Changes in Hippocampal Neurogenesis, Bdnf Expression, and Cognition

Suri, Deepika ; Veenit, Vandana ; Sarkar, Ambalika ; Thiagarajan, Devi ; Kumar, Arvind ; Nestler, Eric J. ; Galande, Sanjeev ; Vaidya, Vidita A. (2013) Early Stress Evokes Age-Dependent Biphasic Changes in Hippocampal Neurogenesis, Bdnf Expression, and Cognition Biological Psychiatry, 73 (7). pp. 658-666. ISSN 0006-3223

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Official URL: http://doi.org/10.1016/j.biopsych.2012.10.023

Related URL: http://dx.doi.org/10.1016/j.biopsych.2012.10.023

Abstract

Adult-onset stressors exert opposing effects on hippocampal neurogenesis and cognition, with enhancement observed following mild stress and dysfunction following severe chronic stress. While early life stress evokes persistent changes in anxiety, it is unknown whether early stress differentially regulates hippocampal neurogenesis, trophic factor expression, and cognition across the life span.

Item Type:Article
Source:Copyright of this article belongs to Society of Biological Psychiatry.
ID Code:119039
Deposited On:07 Jun 2021 07:46
Last Modified:07 Jun 2021 07:46

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