Postnatal Fluoxetine-Evoked Anxiety Is Prevented by Concomitant 5-HT2A/C Receptor Blockade and Mimicked by Postnatal 5-HT2A/C Receptor Stimulation

Sarkar, Ambalika ; Chachra, Parul ; Vaidya, Vidita A. (2014) Postnatal Fluoxetine-Evoked Anxiety Is Prevented by Concomitant 5-HT2A/C Receptor Blockade and Mimicked by Postnatal 5-HT2A/C Receptor Stimulation Biological Psychiatry, 76 (11). pp. 858-868. ISSN 0006-3223

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Official URL: http://doi.org/10.1016/j.biopsych.2013.11.005

Related URL: http://dx.doi.org/10.1016/j.biopsych.2013.11.005

Abstract

Postnatal treatment with the selective serotonin reuptake inhibitor fluoxetine, evokes anxiety and depressive behavior in rodent models in adulthood. We examined the role of serotonin 2A (5-HT2A), serotonin 2C (5-HT2C) and serotonin 1A (5-HT1A) receptors, implicated in the development of anxiety, in the behavioral consequences of postnatal fluoxetine (PNFlx).

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