Neuropharmacology of schizophrenia: is there a role for leptin?

Venkatasubramanian, Ganesan ; Arasappa, Rashmi ; Christopher, Rita ; Gangadhar, Bangalore N. (2010) Neuropharmacology of schizophrenia: is there a role for leptin? Clinical Chemistry and Laboratory Medicine, 48 (6). ISSN 1434-6621

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A significant relationship between beneficial therapeutic effects and antipsychotic-induced weight gain has been demonstrated in various studies for various medications including clozapine, olanzapine and risperido new summarized in (1)x.Of interest, leptin has been postulated as a potential mediator underlying this intriguing link between weight gain and better clinical outcome (1). In this letter, we describe for the first time a significant positive correlation between base line serum leptin concentrations and improvements in positive symptoms in patients with schizophrenia following antipsychotic treatment.

Item Type:Article
Source:Copyright of this article belongs to Walter de Gruyter GmbH.
Keywords:Leptin; Schizophrenia.
ID Code:118842
Deposited On:30 May 2021 07:44
Last Modified:30 May 2021 07:44

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