A Case of Successful Treatment of Comorbid Obesity and Polycystic Ovarian Disease With Add-On Metformin in Bipolar Disorder

Abstract

To the Editor: The association between bipolar disorder and polycystic ovarian disease has been a matter of considerable debate.1 It has been hypothesized that a genetic overlay may explain co-occurrence of both disorders.2 Treatment of bipolar disorder with valproate has also been described to be associated with increased incidence of polycystic ovarian disease.3 The co-occurrence of both disorders significantly enhances risk of associated metabolic complications, especially since bipolar disorder, by itself, has been reported to be associated with increased risk of obesity.4 In this report, we describe successful treatment of polycystic ovarian disease and obesity with add-on metformin in a female patient with DSM-IV bipolar disorder.