Entorhinal Cortex Volume in Antipsychotic-naäve Schizophrenia

Jose, Sam P. ; Sharma, Eesha ; Narayanaswamy, Janardhanan C. ; Rajendran, Vishnurajan ; Kalmady, Sunil V. ; Rao, Naren P. ; Venkatasubramanian, Ganesan ; Gangadhar, Bangalore N. (2012) Entorhinal Cortex Volume in Antipsychotic-naäve Schizophrenia Indian Journal of Psychological Medicine, 34 (2). pp. 164-169. ISSN 0253-7176

Full text not available from this repository.

Official URL: http://doi.org/10.4103/0253-7176.101787

Related URL: http://dx.doi.org/10.4103/0253-7176.101787


Background: Entorhinal cortex (ERC), a multimodal sensory relay station for the hippocampus, is critically involved in learning, emotion, and novelty detection. One of the pathogenetic mechanistic bases in schizophrenia is proposed to involve aberrant information processing in the ERC. Several studies have looked at cytoarchitectural and morphometric changes in the ERC, but results have been inconsistent possibly due to the potential confounding effects of antipsychotic treatment. Materials and methods: In this study, we have examined the entorhinal cortex volume in antipsychotic-naïve schizophrenia patients (n=40; M:F=22:18) in comparison with age, sex, and handedness, matched (as a group) with healthy subjects (n=42; M:F=25:17) using a valid method. 3-Tesla MR images with 1-mm sections were used and the data was analyzed using the SPSS software. Results: Female schizophrenia patients (1.25±0.22 mL) showed significant volume deficit in the right ERC in comparison with female healthy controls (1.45±0.34 mL) (F=4.9; P=0.03), after controlling for the potential confounding effects of intracranial volume. However, male patients did not differ from male controls. The left ERC volume did not differ between patients and controls. Conclusions: Consistent with the findings of a few earlier studies we found a reduction in the right ERC volume in patients. However, this was limited to women. Contextually, our study finding supports the role for ERC deficit in schizophrenia pathogenesis - perhaps mediated through aberrant novelty detection. Sex-differential observation of ERC volume deficit in schizophrenia needs further studies.

Item Type:Article
Source:Copyright of this article belongs to Indian Psychiatric Society, South Zonal Branch.
Keywords:Entorhinal Cortex; Hippocampus; Schizophrenia.
ID Code:118791
Deposited On:30 May 2021 04:24
Last Modified:30 May 2021 04:24

Repository Staff Only: item control page