Rimonabant-induced depression in schizophrenia

Venkatasubramanian, Ganesan ; Reddy, NaliniN ; Behere, RishikeshV ; Sivakumar, PalanimuthuT ; Gangadhar, BangaloreN ; Arasappa, Rashmi ; Rao, NarenP (2014) Rimonabant-induced depression in schizophrenia Indian Journal of Psychiatry, 56 (2). p. 205. ISSN 0019-5545

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Official URL: http://doi.org/10.4103/0019-5545.130513

Related URL: http://dx.doi.org/10.4103/0019-5545.130513


Sir, Cannabinoids modulate mood probably through serotonergic neurons in medial prefrontal cortex and cannabinoid receptor (CB1) receptor antagonists may reverse these effects. [1] Rimonabant, a CB1 receptor antagonist and an anti-obesity agent has been associated with depressive and anxiety symptoms in clinical trials [2] though was initially considered to be safe. [3] We report a patient with schizophrenia developing depression possibly due to rimonabant.

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