Serum vitamin D and hippocampal gray matter volume in schizophrenia

Shivakumar, Venkataram ; Kalmady, Sunil V. ; Amaresha, Anekal C. ; Jose, Dania ; Narayanaswamy, Janardhanan C. ; Agarwal, Sri Mahavir ; Joseph, Boban ; Venkatasubramanian, Ganesan ; Ravi, Vasanthapuram ; Keshavan, Matcheri S. ; Gangadhar, Bangalore N. (2015) Serum vitamin D and hippocampal gray matter volume in schizophrenia Psychiatry Research: Neuroimaging, 233 (2). pp. 175-179. ISSN 0925-4927

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Disparate lines of evidence including epidemiological and case-control studies have increasingly implicated vitamin D in the pathogenesis of schizophrenia. Vitamin D deficiency can lead to dysfunction of the hippocampus – a brain region hypothesized to be critically involved in schizophrenia. In this study, we examined for potential association between serum vitamin D level and hippocampal gray matter volume in antipsychotic-naïve or antipsychotic-free schizophrenia patients (n=35). Serum vitamin D level was estimated using 25-OH vitamin D immunoassay. Optimized voxel-based morphometry was used to analyze 3-Tesla magnetic resonance imaging (MRI) (1-mm slice thickness). Ninety-seven percent of the schizophrenia patients (n=34) had sub-optimal levels of serum vitamin D (83%, deficiency; 14%, insufficiency). A significant positive correlation was seen between vitamin D and regional gray matter volume in the right hippocampus after controlling for age, years of education and total intracranial volume (Montreal Neurological Institute (MNI) coordinates: x=35, y=−18, z=−8; t=4.34 pFWECorrected=0.018). These observations support a potential role of vitamin D deficiency in mediating hippocampal volume deficits, possibly through neurotrophic, neuroimmunomodulatory and glutamatergic effects.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Schizophrenia; Vitamin D; Hippocampus.
ID Code:118481
Deposited On:21 May 2021 10:51
Last Modified:21 May 2021 10:51

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