Salmonella Typhimurium: Insight into the multi-faceted role of the LysR-type transcriptional regulators in Salmonella

Abstract

The LysR-type transcriptional regulators (LTTRs) are widely distributed in various genera of prokaryotes. LTTRs are DNA binding proteins that can positively or negatively regulate target gene expression and can also repress their own transcription. Salmonella enterica comprises a group of Gram-negative bacteria capable of causing clinical syndromes that range from self-limiting diarrhoea to severe fibrinopurulent necrotizing enteritis and life threatening systemic disease. The survival and replication of Salmonella in macrophages and in infected host is brought about by the means of various two component regulatory systems, transporters and other virulence islands. In Salmonella genome the existence of 44 LTTRs has been documented. These LTTRs regulate bacterial stress response, systemic virulence in mice and also many virulence determinants in vitro. Here we focus on the findings that elucidate the structure and function of the LTTRs in Salmonella and discuss the importance of these LTTRs in making Salmonella a successful pathogen.