Eswarappa, Sandeepa M. ; Janice, Jessin ; Balasundaram, Sudhagar V. ; Chakravortty, Dipshikha (2013) Non-neutral evolution in non-LEE-encoded type III effectors of attaching and effacing Escherichia coli Microbes and Infection, 15 (2). pp. 147-151. ISSN 1286-4579
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Official URL: http://doi.org/10.1016/j.micinf.2012.10.015
Related URL: http://dx.doi.org/10.1016/j.micinf.2012.10.015
Abstract
Attaching and effacing Escherichia coli (AEEC) employ type III secretion system (T3SS) to secrete effector proteins into host cells and regulate their function. Here we have investigated T3SS genes of AEEC for non-neutral evolution. Our analysis revealed non-neutral evolution in three genes (nleE1, nleB2 and nleD) which encode effector proteins. These genes are located outside the locus of enterocyte effacement (LEE). In general, non-LEE effector genes show greater deviation from neutral evolution than LEE effector genes. These results suggest that effector genes located outside LEE are under greater selection pressure than those present in LEE.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Type 3 Secretion System; Non-Neutral Evolution; E. coli; Non-LEE-Encoded Effectors. |
| ID Code: | 118337 |
| Deposited On: | 20 May 2021 10:00 |
| Last Modified: | 20 May 2021 10:00 |
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