Banik, Ananya ; Paira, Rupankar ; Shaw, Bikash Kumar ; Vijaykumar, Gonela ; Mandal, Swadhin K. (2018) Accessing Heterobiaryls through Transition-Metal-Free C–H Functionalization Journal of Organic Chemistry, 83 (6). pp. 3236-3244. ISSN 0022-3263
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Official URL: http://doi.org/10.1021/acs.joc.8b00140
Related URL: http://dx.doi.org/10.1021/acs.joc.8b00140
Abstract
Herein we report a transition-metal-free synthetic protocol for heterobiaryls, one of the most important pharmacophores in the modern drug industry, employing a new multidonor phenalenyl (PLY)-based ligand. The current procedure offers a wide substrate scope (24 examples) with a low catalyst loading resulting in an excellent product yield (up to 95%). The reaction mechanism involves a single electron transfer (SET) from a phenalenyl-based radical to generate a reactive heteroaryl radical. To establish the mechanism, we have isolated the catalytically active SET initiator, characterizing by a magnetic study.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 118282 |
| Deposited On: | 19 May 2021 16:53 |
| Last Modified: | 19 May 2021 16:53 |
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