3-Piperidylethoxypterocarpan: A potential bone anabolic agent that improves bone quality and restores trabecular micro-architecture in ovariectomized osteopenic rats

Raghuvanshi, Ashutosh ; Kumar, Amit ; Tyagi, Abdul M. ; Kureel, Jyoti ; Awasthi, Pallavi ; Purohit, Deepak ; Mansoori, Mohd Nizam ; Shukla, Priyanka ; Srivastava, Kamini ; Gautam, Abnish K. ; Saxena, Ruchi ; Dwivedi, Anila ; Singh, Divya ; Goel, Atul (2017) 3-Piperidylethoxypterocarpan: A potential bone anabolic agent that improves bone quality and restores trabecular micro-architecture in ovariectomized osteopenic rats Molecular and Cellular Endocrinology, 448 . pp. 41-54. ISSN 0303-7207

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Official URL: http://doi.org/10.1016/j.mce.2017.03.010

Related URL: http://dx.doi.org/10.1016/j.mce.2017.03.010

Abstract

A series of new 6H-benzofuro[3, 2-c]chromenes (BFC, pterocarpans) with structure-activity relationships were investigated for their potential use in osteoporosis treatment. One of the BFCs 3-piperidylethoxypterocarpan 20 promotes osteoblast differentiation and mineralization at a dose as low as 1 pM via activation of ER/P38MAPK/BMP-2 pathway. When evaluated for in-vivo osteogenic activity in female Sprague-Dawley rats, BFC 20 increased bone mineral density and new bone formation, compared with control at 1.0 and 10.0 mg/kg/body weight by oral gavage for 30 days. The compound was devoid of any uterotrophic effect and led to the new bone formation in adult ovariectomized osteopenic rats. BFC 20 compound also inhibited bone resorption by reducing Ovx induced increase in urinary CTx, thus exhibiting both bone anabolic and anti-catabolic action. Finally, BFC 20 treatment to Ovx rats led to improved trabecular microarchitectural restoration and exhibited therapeutic potential as a dual acting anti-osteoporotic agent for the management of osteoporosis.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:BMP-2 Activator; Benzofurochromene; Bone Anabolic Agent; Osteoporosis; Ovariectomized.
ID Code:117973
Deposited On:07 May 2021 09:56
Last Modified:07 May 2021 09:56

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