Unprecedented Bridged Annulation Approach to the Construction of 5,6-Dihydro-4H-benzo[kl]acridines

Goel, Atul ; Singh, Salil Pratap ; Kumar, Amit ; Kant, Ruchir ; Maulik, Prakas R. (2009) Unprecedented Bridged Annulation Approach to the Construction of 5,6-Dihydro-4H-benzo[kl]acridines Organic Letters, 11 (22). pp. 5122-5125. ISSN 1523-7060

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Official URL: http://doi.org/10.1021/ol901916p

Related URL: http://dx.doi.org/10.1021/ol901916p

Abstract

A general and novel “bridged annulation” methodology for the synthesis of 5,6-dihydro-4H-benzo[kl]acridines has been developed via Michael addition of a conjugate base of 9-methyl-3,4-dihydroacridin-1(2H)-one to various cyclic or acyclic α,β-unsaturated carbonyl/nitrile compounds under mild conditions at room temperature in a short time. To the best of our knowledge, such a general bridged annulation for the synthesis of fused N-heterocycles has not been reported in the literature.

Item Type:Article
Source:Copyright of this article belongs to American Chemical Society.
ID Code:117942
Deposited On:06 May 2021 10:17
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