5,6-Diarylanthranilo-1,3-dinitriles as a new class of antihyperglycemic agents

Singh, Fateh V. ; Parihar, Amrita ; Chaurasia, Sumit ; Singh, Amar B. ; Singh, Salil P. ; Tamrakar, Akhilesh K. ; Srivastava, Arvind K. ; Goel, Atul (2009) 5,6-Diarylanthranilo-1,3-dinitriles as a new class of antihyperglycemic agents Bioorganic & Medicinal Chemistry Letters, 19 (8). pp. 2158-2161. ISSN 0960-894X

Full text not available from this repository.

Official URL: http://doi.org/10.1016/j.bmcl.2009.02.118

Related URL: http://dx.doi.org/10.1016/j.bmcl.2009.02.118


Various functionalized mono- and diarylanthranilo-1,3-dinitriles were synthesized and evaluated for their in vitro antihyperglycemic activity against the PTP-1B, glucose-6-phosphatase, glycogen phosphorylase and α-glucosidase enzymes. Among various screened compounds, 5,6-diaryl substituted anthranilo-1,3-dinitriles 3a, 3b, and 3d showed good inhibitory activity against PTP-1B with IC50 values of 58–72 μM. Three of the test compounds showed significant (25–37%) lowering of plasma glucose level at 24 h in sucrose-challenged streptozotocin-induced diabetic Sprague–Dawley rat model.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Diarylanthranilo-1,3-dinitriles1,2-Teraryl; PTP 1B Inhibitor; STZ-S Model; Antihyperglycemic.
ID Code:117938
Deposited On:06 May 2021 09:53
Last Modified:06 May 2021 09:53

Repository Staff Only: item control page