Synthesis of benzofuran scaffold-based potential PTP-1B inhibitors

Dixit, Manish ; Tripathi, Brajendra K. ; Tamrakar, Akhilesh K. ; Srivastava, Arvind K. ; Kumar, Brijesh ; Goel, Atul (2007) Synthesis of benzofuran scaffold-based potential PTP-1B inhibitors Bioorganic & Medicinal Chemistry, 15 (2). pp. 727-734. ISSN 0968-0896

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Protein tyrosine phosphatase 1B (PTP-1B) is an enzyme that plays a critical role in down-regulating insulin signaling through dephosphorylation of the insulin receptor. Studies have shown that PTP-1B knockout mice showed increased insulin sensitivity in muscle and liver as well as resistance to obesity. A series of hydroxy benzofuran methyl ketones and their naturally mimicking dimers and linear and angular furanochalcones and flavones have been evaluated as PTP-1B inhibitors. Screened compounds displayed good inhibitory activity.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Diabetes; Protein Tyrosine Phosphatase 1B; Insulin Resistance; Benzofuran And Furanoflavonoid.
ID Code:117921
Deposited On:06 May 2021 08:46
Last Modified:06 May 2021 08:46

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