Synthesis of bridgedhead azolo[3,2-a]pyrimidines and imidazo[2,1-b]thiazines through ring transformation of 2H-pyran-2-ones

Ram, Vishnu Ji ; Srivastava, Pratibha ; Goel, Atul (2003) Synthesis of bridgedhead azolo[3,2-a]pyrimidines and imidazo[2,1-b]thiazines through ring transformation of 2H-pyran-2-ones Tetrahedron, 59 (36). pp. 7141-7146. ISSN 0040-4020

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Official URL: http://doi.org/10.1016/S0040-4020(03)01101-3

Related URL: http://dx.doi.org/10.1016/S0040-4020(03)01101-3

Abstract

Suitably functionalized 3-carbomethoxy/cyano-2H-pyran-2-ones are excellent synthons for the synthesis of arenes and heteroarenes of therapeutic importance. The compounds 6-aryl-3-cyano-4-methylsulfanyl-2H-pyran-2-ones have been transformed into bridgedhead azolopyrimidines and imidazothiazines through thermal and base-induced ring transformation reactions with aminoazoles and imidazolidin-2-thiones, respectively.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:azolo[3,2-a]pyrimidine; imidazo[2,1-b]thiazines; 2H-pyran-2-one.
ID Code:117902
Deposited On:06 May 2021 07:12
Last Modified:06 May 2021 07:12

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