Functionalized 1,3-teraryls as a new class of hepatoprotectants: Part V

Ram, Vishnu J. ; Goel, Atul ; Patnaik, (Late) G.K. (1998) Functionalized 1,3-teraryls as a new class of hepatoprotectants: Part V Bioorganic & Medicinal Chemistry Letters, 8 (5). pp. 469-472. ISSN 0960-894X

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Official URL: http://doi.org/10.1016/S0960-894X(98)00061-4

Related URL: http://dx.doi.org/10.1016/S0960-894X(98)00061-4

Abstract

Functionalized 1,3-teraryls, synthesized through ring transformation of 6-aryl-3-carbomethoxy-4-methylthio-2H-pyran-2-one from arylketone have been screened for their hepatoprotective activity and some of them have demonstrated significant protection in animal model. Numerous 1,3-teraryls 3 and 4 have been synthesized and evaluated for their hepatoprotective activity.

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