Confinement induced stochastic sensing of charged coronene and perylene aggregates in α-hemolysin nanochannels

Shivanna, Ravichandran ; Pramanik, Debabrata ; Kumar, Hemant ; Rao, K. Venkata ; George, Subi J. ; Maiti, Prabal K. ; Narayan, K. S. (2013) Confinement induced stochastic sensing of charged coronene and perylene aggregates in α-hemolysin nanochannels Soft Matter, 9 (42). p. 10196. ISSN 1744-683X

Full text not available from this repository.

Official URL: http://doi.org/10.1039/C3SM51313K

Related URL: http://dx.doi.org/10.1039/C3SM51313K

Abstract

Biological nanopores provide optimum dimensions and an optimal environment to study early aggregation kinetics of charged polyaromatic molecules in the nano-confined regime. It is expected that probing early stages of nucleation will enable us to design a strategy for supramolecular assembly and biocrystallization processes. Specifically, we have studied translocation dynamics of coronene and perylene based salts, through the α-hemolysin (α-HL) protein nanopore. The characteristic blocking events in the time-series signal are a function of concentration and bias voltage. We argue that different blocking events arise due to different aggregation processes as captured by all atomistic molecular dynamics (MD) simulations. These confinement induced aggregations of polyaromatic chromophores during the different stages of translocation are correlated with the spatial symmetry and charge distribution of the molecules.

Item Type:Article
Source:Copyright of this article belongs to The Royal Society of Chemistry.
ID Code:117747
Deposited On:30 Apr 2021 11:05
Last Modified:30 Apr 2021 11:05

Repository Staff Only: item control page