Comparison of the EUCAST and CLSI Broth Microdilution Methods for Testing Isavuconazole, Posaconazole, and Amphotericin B against Molecularly Identified Mucorales Species

Chowdhary, Anuradha ; Singh, Pradeep Kumar ; Kathuria, Shallu ; Hagen, Ferry ; Meis, Jacques F. (2015) Comparison of the EUCAST and CLSI Broth Microdilution Methods for Testing Isavuconazole, Posaconazole, and Amphotericin B against Molecularly Identified Mucorales Species Antimicrobial Agents and Chemotherapy, 59 (12). pp. 7882-7887. ISSN 0066-4804

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Official URL: http://doi.org/10.1128/AAC.02107-15

Related URL: http://dx.doi.org/10.1128/AAC.02107-15

Abstract

We compared EUCAST and CLSI antifungal susceptibility testing (AFST) methods for triazoles and amphotericin B against 124 clinical Mucorales isolates. The EUCAST method yielded MIC values 1- to 3-fold dilutions higher than those of the CLSI method for amphotericin B. The essential agreements between the two methods for triazoles were high, i.e., 99.1% (voriconazole), 98.3% (isavuconazole), and 87% (posaconazole), whereas it was significantly lower for amphotericin B (66.1%). Strategies for harmonization of the two methods for Mucorales AFST are warranted.

Item Type:Article
Source:Copyright of this article belongs to American Society for Microbiology.
ID Code:117523
Deposited On:26 Apr 2021 10:03
Last Modified:26 Apr 2021 10:03

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