A multicentre study of antifungal susceptibility patterns among 350 Candida auris isolates (2009–17) in India: role of the ERG11 and FKS1 genes in azole and echinocandin resistance

Chowdhary, Anuradha ; Prakash, Anupam ; Sharma, Cheshta ; Kordalewska, Milena ; Kumar, Anil ; Sarma, Smita ; Tarai, Bansidhar ; Singh, Ashutosh ; Upadhyaya, Gargi ; Upadhyay, Shalini ; Yadav, Priyanka ; Singh, Pradeep K ; Khillan, Vikas ; Sachdeva, Neelam ; Perlin, David S ; Meis, Jacques F (2018) A multicentre study of antifungal susceptibility patterns among 350 Candida auris isolates (2009–17) in India: role of the ERG11 and FKS1 genes in azole and echinocandin resistance Journal of Antimicrobial Chemotherapy, 73 (4). pp. 891-899. ISSN 0305-7453

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Official URL: http://doi.org/10.1093/jac/dkx480

Related URL: http://dx.doi.org/10.1093/jac/dkx480

Abstract

Background Candida auris has emerged globally as an MDR nosocomial pathogen in ICU patients. Objectives We studied the antifungal susceptibility of C. auris isolates (n = 350) from 10 hospitals in India collected over a period of 8 years. To investigate azole resistance, ERG11 gene sequencing and expression profiling was conducted. In addition, echinocandin resistance linked to mutations in the C. auris FKS1 gene was analysed.

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