Healey, Kelley R. ; Kordalewska, Milena ; Jiménez Ortigosa, Cristina ; Singh, Ashutosh ; Berrío, Indira ; Chowdhary, Anuradha ; Perlin, David S. (2018) Limited ERG11 Mutations Identified in Isolates of Candida auris Directly Contribute to Reduced Azole Susceptibility Antimicrobial Agents and Chemotherapy, 62 (10). ISSN 0066-4804
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Official URL: http://doi.org/10.1128/AAC.01427-18
Related URL: http://dx.doi.org/10.1128/AAC.01427-18
Abstract
Multiple Erg11 amino acid substitutions were identified in clinical isolates of Candida auris originating from India and Colombia. Elevated azole MICs were detected in Saccharomyces cerevisiae upon heterologous expression of C. auris ERG11 alleles that encoded for Y132F or K143R substitutions; however, expression of alleles encoding I466M, Y501H, or other clade-defined amino acid differences yielded susceptible MICs. Similar to other Candida species, specific C. auris ERG11 mutations resulted directly in reduced azole susceptibility.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Society for Microbiology. |
| Keywords: | Candida auris; ERG11; Antifungal Resistance; Azoles; Reduced Azole Susceptibility. |
| ID Code: | 117367 |
| Deposited On: | 19 Apr 2021 11:17 |
| Last Modified: | 19 Apr 2021 11:17 |
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